Stem Cells 101
Stem cells are undifferentiated cells that have the capability of developing into a variety of cell types. Mesenchymal stem cells (MSC), specifically, are robust cell types that are present in tissues including adipose, placenta, gonad, bone marrow, and umbilical cord or peripheral blood. Stem cells can detect damaged areas in the body that cause inflammation or discomfort. In response, they have become a communicative tool for the body’s healing.
The field of stem cell research has recently given rise to the expansion of cell therapy, where cellular material is injected into a patient with the intent to help the patient manage a specific medical indication by replacing or repairing damaged tissue, or by immunomodulation. The cellular material generally consists of intact, living cells. In mainstream veterinary medicine, cell therapy is receiving increased acceptance and support.
Due to availability, safety, and multi-potent characteristics, adipose derived stem cells (ADSCs) have become the most popular stem cell for therapy use since 2001. ADSCs are present in adipose tissue at approximately 3-5% and are able to differentiate into cartilage, bone, and fat cells. Both safe and effective, they are grown in cultures to treat arthritis, autoimmune and other immune-modulated diseases, musculoskeletal diseases and inflammatory diseases by reducing inflammation and pain, promoting cartilage regeneration, restoring mobility, modulating the immune system and improving quality of life.
5 MECHANISMS OF STEM CELL INTEGRATION
Anti-Inflammation | Secretion of cytokines, balancing the production of T-cell inflammation
Tissue Differentiation | Differentiation capability into distinctive tissue types
Trophic Support | Support provision for resident cells that respond to injury and tissue damage
Injury Site Homing | Homing ability to injury sites for aid with healing
Immune System Modulation | Positive stimulatory or inhibitory effect on the immune system
*These scientific mechanisms for adipose MSCs are generally accepted reports
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